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Lubricin is a glycoprotein encoded by the PRG4 gene. It has been identified as a component of joint lubrication and synovial homeostasis by reducing friction in joints and preventing synovial cell overgrowth. It is a large, water soluble molecule that acts as a carrier for insoluble surface-active phospholipid (SAPL). Depletion of lubricin function has been associated with camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP), an arthritic-like autosomal recessive disorder.
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Protein Aliases: articular superficial zone protein; hemangiopoietin; Lubricin; megakaryocyte stimulating factor; Megakaryocyte-stimulating factor; proteoglycan 3; Proteoglycan 4; Proteoglycan-4; Superficial zone proteoglycan
Gene Aliases: CACP; DOL54; HAPO; JCAP; lubricin; MSF; PRG4; SZP
UniProt ID: (Human) Q92954, (Mouse) Q9JM99
Entrez Gene ID: (Human) 10216, (Mouse) 96875
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