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Rat anti-mouse CD16-2 antibody, clone AT137, recognizes CD16-2, also known as FcRIV.
FcgRIV, also known as CD16-2, is an intermediate-affinity activating receptor for IgG2a and IgG2b. CD16-2 is the mouse homolog of human FcgRIIIA. CD16-2 is a low-affinity IgE receptor for all allotypes and the ligation of FcgRIV by antigen-IgE immune complexes promotes macrophage-mediated phagocytosis and is involved in lung inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD16-2; CD16a; Fc fragment of IgG, low affinity IIIa, receptor for (CD16); Fc fragment of IgG, low affinity III, receptor for (CD16); Fc gammaRIV; Fc receptor-like 3; FcgammaRIV; IgG Fc receptor III-A; Low affinity immunoglobulin gamma Fc region receptor III-A
Gene Aliases: 4833442P21Rik; CD16-2; FcgammaRIV; Fcgr3a; Fcgr4; FcgRIV; Fcrl3
UniProt ID: (Mouse) A0A0B4J1G0
Entrez Gene ID: (Mouse) 246256
Molecular Function: immunoglobulin receptor superfamily
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