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1 µg/mL of MA5-45411 was sufficient for detection of KCNQ4 in 10 µg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 77kDa.
The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2, an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: DFNA 2; KCNQ 4; KQT like 4; KQT-like 4; potassium channel KQT-like 4; Potassium channel subunit alpha KvLQT4; potassium channel, voltage gated KQT-like subfamily Q, member 4; Potassium voltage-gated channel subfamily KQT member 4; potassium voltage-gated channel, KQT-like subfamily, member 4; potassium voltage-gated channel, subfamily Q, member 4; Voltage-gated potassium channel subunit Kv7.4
Gene Aliases: DFNA2; DFNA2A; KCNQ4; KV7.4
UniProt ID: (Human) P56696, (Mouse) Q9JK97
Entrez Gene ID: (Human) 9132, (Mouse) 60613, (Rat) 298496
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