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FIGURE: 1 / 1
This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression.
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Protein Aliases: homolog of yeast MAF1; MAF1 negative regulator of RNA polymerase III; Repressor of RNA polymerase III transcription MAF1 homolog
Gene Aliases: 1110068E11Rik; AU042856; MAF1
UniProt ID: (Human) Q9H063, (Mouse) Q9D0U6
Entrez Gene ID: (Human) 84232, (Mouse) 68877
Molecular Function: general transcription factor
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