Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: MTTPNKGNKA LKVKREPGEN GTSLTDEELV TMSVRELNQH LRGLSKEEIV QLKQRRRTLK NRGYAASCRV KRVTQKEELE KQKAELQQEV EKLASENASM KLELDALRSK YEALQTFART VARSPVAPAR GPLAAGLGPL VPGKVAATSV ITIVKSKTDA RS; Positive Samples: U-87MG, A-549, HT-29, 293T; Cellular Location: Nucleus
Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).
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Protein Aliases: avian musculoaponeurotic fibrosarcoma virus (v-maf) AS42 oncogene, protein G; basic leucine zipper transcription factor MafG; hMAF; MGC13090; MGC20149; Transcription factor MafG; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G; V-maf musculoaponeurotic fibrosarcoma oncogene homolog G
Gene Aliases: AA545192; C630022N07Rik; hMAF; MAFG
UniProt ID: (Human) O15525, (Mouse) O54790
Entrez Gene ID: (Human) 4097, (Mouse) 17134
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