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Proteintech

MAP3K1 Polyclonal Antibody

10 References

View all (15) MEKK1 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (5)

Application

MAP3K1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 5

MAP3K1 Antibody (19970-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 19970-1-AP (MAP3K1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

MAP3K1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

19970-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated

Form

Liquid

Concentration

0.41 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The antibody recognizes the N-term of MAP3K1.

Target Information

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK1 can phosphorylate and activate MAPKK 1 and MAPKK 2 (MEK1/MEK2) which leads to phosphorylation of MAP kinases. It is also a highly efficient activator of the JNK cascade. The protein contains a putative 1 RING-type zinc finger and 1 SWIM-type zinc finger.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

Cellular and molecular gastroenterology and hepatology

Yuan J,Lv T,Yang J,Wu Z,Yan L,Yang J,Shi Y,Jiang L

Thu Jan 26 00:00:00 UTC 2023

Identification of a novel cuproptosis-related gene signature and integrative analyses in patients with lower-grade gliomas.

Frontiers in immunology

Bao JH,Lu WC,Duan H,Ye YQ,Li JB,Liao WT,Li YC,Sun YP

Wed Feb 15 00:00:00 UTC 2023

The MAP3K1/c-JUN signaling axis regulates glioblastoma stem cell invasion and tumor progression.

Biochemical and biophysical research communications

Zhou S,Niu R,Sun H,Kim SH,Jin X,Yin J

Tue Jul 05 00:00:00 UTC 2022

Extracellular vesicles secreted from mesenchymal stem cells exert anti-apoptotic and anti-inflammatory effects via transmitting microRNA-18b in rats with diabetic retinopathy.

International immunopharmacology

Xu Z,Tian N,Li S,Li K,Guo H,Zhang H,Jin H,An M,Yu X

Wed Dec 01 00:00:00 UTC 2021

LncRNA KCNQ1OT1 activated by c-Myc promotes cell proliferation via interacting with FUS to stabilize MAP3K1 in acute promyelocytic leukemia.

Cell death & disease

Tang D,Luo Y,Jiang Y,Hu P,Peng H,Wu S,Zhang G,Wang Y

Tue Aug 17 00:00:00 UTC 2021

USP4 deficiency exacerbates hepatic ischaemia/reperfusion injury via TAK1 signalling.

Clinical science (London, England : 1979)

Zhou J,Qiu T,Wang T,Chen Z,Ma X,Zhang L,Zou J

Thu Jan 31 00:00:00 UTC 2019

USP4 deficiency exacerbates hepatic ischaemia/reperfusion injury via TAK1 signalling.

Clinical science (London, England : 1979)

Zhou J,Qiu T,Wang T,Chen Z,Ma X,Zhang L,Zou J

Thu Jan 31 00:00:00 UTC 2019

LncRNA SLCO4A1-AS1 predicts poor prognosis and promotes proliferation and metastasis via the EGFR/MAPK pathway in colorectal cancer.

International journal of biological sciences

Tang R,Chen J,Tang M,Liao Z,Zhou L,Jiang J,Hu Y,Liao Q,Xiong W,Tang Y,Nie S

Mon Jun 01 00:00:00 UTC 2020

MicroRNAs profiling in fibroblasts derived from patients with Gorlin syndrome.

Journal of human genetics

Shiohama T,Fujii K,Miyashita T,Takatani T,Ikehara H,Uchikawa H,Motojima T,Uchida T,Shimojo N

Thu Aug 01 00:00:00 UTC 2019

Xihuang pill promotes apoptosis of Treg cells in the tumor microenvironment in 4T1 mouse breast cancer by upregulating MEKK1/SEK1/JNK1/AP-1 pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Su L,Jiang Y,Xu Y,Li X,Gao W,Xu C,Zeng C,Song J,Weng W,Liang W

Fri Jun 01 00:00:00 UTC 2018

Xihuang pill promotes apoptosis of Treg cells in the tumor microenvironment in 4T1 mouse breast cancer by upregulating MEKK1/SEK1/JNK1/AP-1 pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Su L,Jiang Y,Xu Y,Li X,Gao W,Xu C,Zeng C,Song J,Weng W,Liang W

Fri Jun 01 00:00:00 UTC 2018

Xihuang pill promotes apoptosis of Treg cells in the tumor microenvironment in 4T1 mouse breast cancer by upregulating MEKK1/SEK1/JNK1/AP-1 pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Su L,Jiang Y,Xu Y,Li X,Gao W,Xu C,Zeng C,Song J,Weng W,Liang W

Fri Jun 01 00:00:00 UTC 2018

Xihuang pill promotes apoptosis of Treg cells in the tumor microenvironment in 4T1 mouse breast cancer by upregulating MEKK1/SEK1/JNK1/AP-1 pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Su L,Jiang Y,Xu Y,Li X,Gao W,Xu C,Zeng C,Song J,Weng W,Liang W

Fri Jun 01 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: MAP/ERK kinase kinase 1; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1; mitogen activated protein kinase kinase kinase 1; Mitogen-activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase

Gene Aliases: MAP3K1; MAPKKK1; MEKK; MEKK 1; MEKK1; SRXY6

UniProt ID: (Human) Q13233, (Rat) Q62925

Entrez Gene ID: (Human) 4214, (Mouse) 26401, (Rat) 116667

Function(s)

protein kinase activity protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity MAP kinase kinase kinase activity protein binding ATP binding zinc ion binding protein kinase binding nucleotide binding JUN kinase kinase kinase activity ubiquitin-protein transferase activity JUN kinase binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups mitogen-activated protein kinase kinase binding sphingolipid binding metal ion binding mitogen-activated protein kinase binding JUN kinase kinase activity non-receptor serine/threonine protein kinase

Process(es)

MAPK cascade activation of MAPKK activity MyD88-dependent toll-like receptor signaling pathway protein phosphorylation apoptotic process Fc-epsilon receptor signaling pathway cellular response to mechanical stimulus epithelial cell morphogenesis transforming growth factor beta receptor signaling pathway JNK cascade activation of JNKK activity activation of JUN kinase activity regulation of mitotic cell cycle apoptotic mitochondrial changes phosphorylation protein ubiquitination regulation of cell migration positive regulation of actin filament polymerization wound healing regulation of apoptotic process camera-type eye development eyelid development in camera-type eye protein polyubiquitination response to osmotic stress peptidyl-serine phosphorylation negative regulation of actin filament bundle assembly protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of JUN kinase activity positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation positive regulation of viral transcription protein oligomerization

Performance Guarantee

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MAP3K1 Polyclonal Antibody

MAP3K1 Antibody (19970-1-AP) in ICC/IF

Product Details

19970-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Function(s)

Process(es)

Performance Guarantee

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