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Immunogen sequence: QNGKEKLIAY QREFLALKER LRIAEHRISQ RSSELNTIVQ QFKRVGAETN GSKDALNKFS DNTLKLLKEL TSK; Positive Samples: HT-29, K562, Raji, LO2, HeLa; Cellular Location: Golgi apparatus membrane, Single-pass type II membrane protein
This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 2.4.1.145; Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A; alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase; GlcNAc-T IVa; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme A; N-acetylglucosaminyltransferase IVa; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa; UDP-GlcNAc:a-1,3-D-mannoside b-1,4-acetylglucosaminyltransferase IV; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa; UDP-N-acetylglucosamine:alpha1,3-d-mannoside beta1,4-N-acetylglucosaminyltransferase
Gene Aliases: GnT-4a; GNT-IV; GNT-IVA; MGAT4A
UniProt ID: (Human) Q9UM21
Entrez Gene ID: (Human) 11320
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