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MHC (major histocompatibility complex) class II molecules are transmembrane glycoproteins expressed on the surface of professional antigen-presenting cells, such as macrophages, dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15-24 amino acid residues long.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B-L beta chain; B-L beta minor; B-LB21 major; beta 1 domain; Bl-Beta II protein; BLB major; major histocompatibility class II antigen B-L beta; major histocompatibility complex class II B; MHC 2; MHC Class II; MHC class II antigen B-F minor heavy chain; MHC class II antigen beta chain; MHC class II B-L beta chain; MHC Class II beta 1 and 2 domains; MHC class II beta 1 domain; MHC class II beta chain 1; MHC class II beta chain 2; MHC II; MHCCII
Gene Aliases: B-L; B-LB; B-LB2; B-LB21; B-LBII; GSP-BLB1; GSP-BLB2; S19
Entrez Gene ID: (Chicken) 693256, (Chicken) 101747454, (Chicken) 425256
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