Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Immunogen sequence: DSKQGKPQSA TDYSDPDNVD DGLFIVDIPK TNNDKEVNAE HHIKGKGRGV QESKRGLVQD ETELEDENQE GMTVHSSVHS NNLNSMPA
Highest antigen sequence identity to the following orthologs: Mouse - 25%, Rat - 26%.
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255, PubMed:19269366). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C219-reactive peptide; D320; melanoma inhibitory activity family member 3; melanoma inhibitory activity family, member 3; Melanoma inhibitory activity protein 3; RP11-378J18.4; TANGO1; transport and Golgi organization protein 1; Transport and Golgi organization protein 1 homolog
Gene Aliases: ARNT; D320; KIAA0268; MIA3; TANGO; TANGO1; UNQ6077; UNQ6077/PRO20088
UniProt ID: (Human) Q5JRA6
Entrez Gene ID: (Human) 375056
Molecular Function:
membrane traffic protein
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