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MICB Antibody (TA813500) in WB
Western blot analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Cat # PS100001, Left lane) or pCMV6-ENTRY MICB/MICA (Cat # RC222315]/Cat # RC204447 Middle/, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and blotted with anti-MICB antibody (Cat # TA813500)(1:1000).
Product Details
TA813500
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI4E9
Immunogen
Full length human recombinant protein of human MICB (NP_005922) produced in HEK293T cell.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Dilute in PBS (pH7.3) if necessary. Stable for 12 months from date of receipt.
Target Information
MICB encodes the highly polymorphic MHC (HLA) class I chain-related gene B. The protein product is expressed on the cell surface. It is thought that MICB functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. MICB is broadly recognized by NK cells and T cells with NKG2D receptor on their surface. The complex NKG2D-MICB results in MICB expressing cytolytic T cells and NK cells against epithelial tumor cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I polypeptide-related sequence B; MHC class I-like molecule PERB11.2-IMX; MIC-B; MICB; sMICB; soluble MICB; stress inducible class I homolog
Gene Aliases: MICB; PERB11.2
UniProt ID: (Human) Q29980
Entrez Gene ID: (Human) 4277
T cell mediated cytotoxicity
immune response-activating cell surface receptor signaling pathway
response to oxidative stress
response to heat
viral process
cytolysis
antigen processing and presentation
response to retinoic acid
natural killer cell mediated cytotoxicity
gamma-delta T cell activation
negative regulation of defense response to virus by host
regulation of immune response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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