Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
FIGURE: 1 / 1
Immunogen sequence: GTLALAAGAL CREARAAQVF FLKGGYEAFS ASCPELCSKQ STPMGLSLPL STSVPDSAES GCSSCSTPLY DQGGPVEILP FLYLGSAYHA SRKDMLDALG I
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CL 100; Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; DUS1; EC 3.1.3.16; EC 3.1.3.48; MAP kinase phosphatase 1; Mitogen-activated protein kinase phosphatase 1; Protein-tyrosine phosphatase CL100; serine/threonine specific protein phosphatase
Gene Aliases: CL100; DUSP1; HVH1; MKP-1; MKP1; PTPN10; VH1
UniProt ID: (Human) P28562
Entrez Gene ID: (Human) 1843
Molecular Function:
protein phosphatase
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