Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: EQFWKGLPAR IDAAYERADG RFVFFKGDKY WVFKEVTVEP GYPHSLGELG SCLPREGIDT ALRWEPVGKT YFFKGERYWR YSEERRATDP GYPKPITVWK GIPQAPQGAF ISKEGYYTYF YKGRDYWKFD NQKLSVEPGY PRNILRDWMG CNQKEVERRK ERRLPQDDVD IMVTINDVPG SVNA
All cells within tissues are surrounded by an extracellular matrix (ECM) giving the tissues shape and structure. The ECM is constantly being remodeled and constant communication is maintained between cells through this matrix. Secreted proteins, termed matrix metalloproteinases (MMPs), are involved in the modulation of cell-matrix interactions. MMPs are Zn (2+)-binding endopeptidases that degrade various components of the ECM. MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. These enzymes are very potent when active, and are associated with extracellular space inhibitors called TIMPs (tissue inhibitors of matrix metalloproteinases). TIMPs have been shown to block tumor cell invasion suggesting that they act as metastasis suppressor genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: matrix metallo protease; matrix metallopeptidase 24 (membrane-inserted); matrix metalloproteinase 24; matrix metalloproteinase 24 (membrane-inserted); Matrix metalloproteinase-21; Matrix metalloproteinase-24; membrane type 5-MMP; membrane-type 5 matrix metalloproteinase; Membrane-type matrix metalloproteinase 5; Membrane-type-5 matrix metalloproteinase; MMP; MMP-21; MMP-24; MMPs; MT-MMP 5; MT5-MMP; RP4-614O4.10
Gene Aliases: AU040325; MMP-24; Mmp21; MMP24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP; MT5MMP; MTMMP5
UniProt ID: (Human) Q9Y5R2, (Rat) Q99PW6, (Mouse) Q9R0S2
Entrez Gene ID: (Human) 10893, (Rat) 83513, (Mouse) 17391
Molecular Function:
metalloprotease
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