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Immunogen sequence: SRIHLDWKVL FCHVHLVSIF LSALNSSANP IIYFFVGSFR QRQNRQNLKL VLQRALQDTP EVDEGGGQLP QETLELSGSR LEQ
Orphan receptor activated by a subset of RFamide-family neuropeptides such as FLRF-amide and FMRF-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. May regulate the function of nociceptive neurons by modulation of pain perception. Expressed in a subset of IB4-positive small diameter nociceptive dorsal root neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: adenine receptor; G protein-coupled receptor MRGX3; G protein-coupled receptor SNSR1; G protein-coupled receptor SNSR2; G-protein coupled receptor; G-protein coupled receptor; rc 56.1.3; Hdrr1; HDRR2; Mas-related G protein-coupled receptor g1; Mas-related G-protein coupled receptor member A; Mas-related G-protein coupled receptor member X3; MAS-related G-protein coupled receptor, member A; Mas-related gene A; mas-related GPCR member X3; MAS-related GPR, member X3; MGC108580; nuclear receptor MrgA10 RF-amide G protein-coupled receptor; rc 56.1.3; Sensory neuron-specific G-protein coupled receptor 1/2
Gene Aliases: GPCR; Mgrg1; MrgA; Mrga10; Mrgpra; MRGPRX3; MRGX3; SNSR1; SNSR2
UniProt ID: (Human) B0M0L1, (Rat) Q7TN49
Entrez Gene ID: (Human) 117195, (Rat) 252960
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