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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q.
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Protein Aliases: 39S ribosomal protein L15, mitochondrial; L15mt; Large ribosomal subunit protein uL15m
Gene Aliases: HSPC145; L15mt; MRP-L15; MRP-L7; MRPL15; RPML7
UniProt ID: (Human) Q9P015
Entrez Gene ID: (Human) 29088
Molecular Function:
ribosomal protein
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