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FIGURE: 1 / 3
Antibody detects endogenous levels of total MRPL39.
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q.
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Protein Aliases: 39S ribosomal protein L39, mitochondrial; 39S ribosomal protein L5, mitochondrial; L39mt; L5mt; Large ribosomal subunit protein mL39; mitochondrial ribosomal protein L39; MRP-L39; ribosomal protein, mitochondrial, L5
Gene Aliases: C21orf8; C21orf92; L39mt; MRP-L5; MRPL39; MRPL5; MSTP003; ORF22; PRED22; PRED66; RPML5
UniProt ID: (Human) Q9NYK5, (Mouse) Q9JKF7
Entrez Gene ID: (Human) 54148, (Rat) 684304, (Mouse) 27393
Molecular Function:
aminoacyl-tRNA synthetase
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