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Product Details
17554-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MTA2 Fusion Protein Ag11713 (1-350 aa encoded by BC053650)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAANMYRVG DYVYFENSSS NPYLVRRIEE LNKTANGNVE AKVVCLFRRR DISSSLNSLA DSNAREFEEE SKQPGVSEQQ RHQLKHRELF LSRQFESLPA THIRGKCSVT LLNETDILSQ YLEKEDCFFY SLVFDPVQKT LLADQGEIRV GCKYQAEIPD RLVEGESDNR NQQKMEMKVW DPDNPLTDRQ IDQFLVVARA VGTFARALDC SSSIRQPSLH MSAAAASRDI TLFHAMDTLQ RNGYDLAKAM STLVPQGGPV LCRDEMEEWS ASEAMLFEEA LEKYGKDFND IRQDFLPWKS LASIVQFYYM WKTTDRYIQQ KRLKAAEADS KLKQVYIPTY TKPNPNQIIS V (1-350 aa encoded by BC053650)
Target Information
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp686F2281; metastais-associated gene family, member 2; metastasis -associated gene 1-like 1; metastasis associated 1 family, member 2; metastasis associated 1-like 1; metastasis associated gene family, member 2; Metastasis-associated 1-like 1; metastasis-associated gene family, member 2; metastasis-associated protein 2; Metastasis-associated protein MTA2; MTA1-L1 protein; p53 target protein in deacetylase complex
Gene Aliases: AW550797; Mata1l1; mmta2; MTA1L1; MTA2; PID
UniProt ID: (Human) O94776, (Mouse) Q9R190
Entrez Gene ID: (Human) 9219, (Rat) 361724, (Mouse) 23942
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcription factor activity, transcription factor binding
RNA polymerase II transcription factor binding
RNA polymerase II repressing transcription factor binding
transcription factor activity, sequence-specific DNA binding
histone deacetylase activity
protein binding
zinc ion binding
nucleosomal DNA binding
histone deacetylase binding
transcription regulatory region DNA binding
DNA binding
chromatin binding
sequence-specific DNA binding
metal ion binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
DNA methylation
chromatin assembly or disassembly
regulation of fibroblast migration
histone deacetylation
ATP-dependent chromatin remodeling
positive regulation of transcription from RNA polymerase II promoter
regulation of signal transduction by p53 class mediator
negative regulation of transcription, DNA-templated
DNA packaging
chromatin remodeling
regulation of transcription, DNA-templated
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