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Proteintech
MTF2 Recombinant Rabbit Monoclonal Antibody (230138D10)
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Product Details
82944-1-RR
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
230138D10
Immunogen
MTF2 fusion protein Ag9384
Conjugate
Unconjugated
Form
Liquid
Concentration
0.8 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: ADLEWDAGHK TNVQQCYCYC GGPGDWYLKM LQCCKCKQWF HEACVQCLQK PMLFGDRFYT FICSVCSSGP EYLKRLPLQW VDIAHLCLYN LSVIHKKKYF DSELELMTYI NENWDRLHPG ELADTPKSER YEHVLEALND YKTMEVSNGI EKKGKKKSVG RPPGPYTRKM IQKTAEPLLD KESISENPTL DLPCSIGRTE GTAHSSNTSD VDFTGASSAK ETTSSSISRH YGLSDSRKRT RTGRSWPAAI PHLRRRRGRL PRRALQTQNS EIVKDDEGKE DYQFDELNTE ILNNLADQEL QLNHLKNSIT SYFGAAGRIA CGEKYRVLAR RVTLDGKVQY LVEWEGATAS
Target Information
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hPCl2; Metal regulatory transcription factor 2; metal response element-binding transcription factor 2; Metal-response element DNA-binding protein M96; Metal-response element-binding transcription factor 2; polycomb-like 2; Polycomb-like protein 2; putative DNA binding protein; RP5-976O13.1; tudor domain containing 19A
Gene Aliases: dJ976O13.2; M96; MTF2; PCL2; TDRD19A
UniProt ID: (Human) Q9Y483
Entrez Gene ID: (Human) 22823
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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