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Product Details
H00004613-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
3H4
Immunogen
MYCN (NP_005369, 1 a.a. approximately 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: MPSCSTSTMP GMICKNPDLE FDSLQPCFYP DEDDFYFGGP DSTPPGEDIW KKFELLPTPP LSPSRGFAEH SSEPPSWVTE MLLENELWGS PAEEDAFGLG
Target Information
N-Myc protein is member of the MYC family of transcription factor proteins with a basic helix-loop-helix (bHLH) domain. N-Myc is similarly regulated and functionally complementary to C-Myc in the context of various cellular growth and differentiation processes. MYCN gene is considered the hallmark of neuroblastoma, amplification and overexpression of the MYCN proto-oncogene occurs in approximately 20% of neuroblastomas and is associated with advanced stage disease, rapid tumor progression, and poor prognosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHe37; Class E basic helix-loop-helix protein 37; N-myc proto-oncogene protein; neuroblastoma MYC oncogene; neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene; oncogene NMYC; oncogene pp65/67; pp65/67
Gene Aliases: BHLHE37; MODED; MYCN; N-myc; NMYC; ODED
UniProt ID: (Human) P04198
Entrez Gene ID: (Human) 4613
cartilage condensation
positive regulation of mesenchymal cell proliferation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of gene expression
positive regulation of cell death
lung development
embryonic digit morphogenesis
regulation of auditory receptor cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic skeletal system morphogenesis
negative regulation of astrocyte differentiation
branching morphogenesis of an epithelial tube
negative regulation of reactive oxygen species metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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