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OriGene

MYD88 Monoclonal Antibody (OTI2B2), TrueMAB™

2 References

View all (38) MyD88 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (10)

Application

MYD88 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 10

MYD88 Antibody (TA502117) in ICC/IF

Anti-MYD88 mouse monoclonal antibody (TA502117) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MYD88(RC202253).

MYD88 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

TA502117

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

1:150

Immunocytochemistry (ICC/IF)

1:100

Flow Cytometry (Flow)

1:100

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

OTI2B2

Immunogen

Full length human recombinant protein of human MYD88 produced in HEK293T cell.

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Myeloid differentiation Marker 88 (MyD88) is an adaptor molecule for the Toll/IL-1R and is involved in the inflammatory response induced by IL-1, IL-18 and LPS. MyD88 recruits IRAK to IL-1 receptor complex in response to IL-1. This pathway further leads to activation of NF-kB. MyD88 has a wide tissue distribution.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Proximal Ligation Assay (PLA) on Lung Tissue and Cultured Macrophages to Demonstrate Protein-protein Interaction.

Bio-protocol

Mendez R,Banerjee S

Sun Nov 05 00:00:00 UTC 2017

MYD88 expression and L265P mutation in mature B-cell non-Hodgkin lymphomas.

Genetic testing and molecular biomarkers

Caner V,Sen Turk N,Baris IC,Cetin GO,Tepeli E,Hacioglu S,Sari I,Zencir S,Dogu MH,Bagci G,Keskin A

Wed Jul 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: mutant myeloid differentiation primary response 88; myeloid differentiation primary response gene (88); Myeloid differentiation primary response protein MyD88

Gene Aliases: MYD88; MYD88D

UniProt ID: (Human) Q99836

Entrez Gene ID: (Human) 4615

Function(s)

death receptor binding protein binding identical protein binding protein self-association TIR domain binding scaffold/adaptor protein

Process(es)

toll-like receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway apoptotic process inflammatory response signal transduction cell surface receptor signaling pathway positive regulation of type I interferon production positive regulation of interleukin-17 production positive regulation of interleukin-23 production positive regulation of interleukin-6 production toll-like receptor 9 signaling pathway negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of inflammatory response defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity response to interleukin-1 3'-UTR-mediated mRNA stabilization cellular response to mechanical stimulus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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