Hamburger Menu Button
Thermo Fisher Scientific Logo
登入
Don't have an account ? Create Account
  • Products
    • Antibodies
    • Oligos, Primers, Probes and Genes
    • TaqMan Real-Time PCR Assays
    • Cell Culture Media
    • Chemicals
    • Chromatography Columns and Cartridges
    • Lab Equipment
    • Lab Plasticware and Supplies
    • Microplates
    • Tubes
    • See all product categories
  • Applications
    • Bioprocessing
    • Cell Culture and Transfection
    • Cell and Gene Therapy
    • Chromatography
    • Clinical Genomics
    • Digital Solutions
    • DNA and RNA Extraction and Analysis
    • Spectroscopy, Elemental and Isotope Analysis
    • See all applications and techniques
  • Services
    • 360° CDMO 和 CRO 服務
    • CDMO 服務
    • 臨床試驗 CRO 服務
    • Custom Services
    • Enterprise Services
    • Financial and Leasing Services
    • Instrument Services
    • Lab Informatics
    • OEM and Commercial Supply
    • Training Services
    • Unity Lab Services
    • See all services
  • Help and Support
    • Register for an Account
    • How to Order
    • Instrument Support
    • Technical Support Centers
    • Learning Centers
    • See all help and support topics
  • Popular
    • TaqMan Real-Time PCR Assays
      TaqMan Real-Time PCR Assays
    • Antibodies
      Antibodies
    • Oligos, Primers & Probes
      Oligos, Primers & Probes
    • GeneArt Gene Synthesis
      GeneArt Gene Synthesis
    • Cell Culture Plastics
      Cell Culture Plastics
  • Contact Us
  • Quick Order
  • Order Status and Tracking
  • Documents and Certificates
Thermo Fisher Scientific Logo

Search Thermo Fisher Scientific

Primary Antibodies
  • Search All
  • Popular Product Areas
  • TaqMan Assays
  • Primary Antibodies
  • Secondary Antibodies
  • Isotype Controls
  • Proteins and Peptides
  • ELISA Kits
  • All Documents & Support
  • Certificates
  • SDS
  • Product FAQs
  • Documents & Support
  • Manuals & Protocols
    Search button Close
            Target of Interest
            Application
            Target Species
            • Order Status
            • 快速訂購
            • 登入
              登入
              Don't have an account ? Create Account
              • 帳戶
              • 訂單
              • 訂製產品與專案

            Disclaimer

            Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

            Loading ...
            • Primary Antibodies ›
            • MEL18 Antibodies

            Bethyl Laboratories

            Mel-18 Polyclonal Antibody

            View all (9) MEL18 antibodies
            Datasheet
            Protocols
            Questions & Answers
            Tech Support
            Datasheet
            Protocols
            Questions & Answers
            Tech Support

            Cite Mel-18 Polyclonal Antibody

            • Antibody Testing Data (1)
            Application
            Mel-18 Antibody in Western Blot (WB)
            Group 53 Created with Sketch.

            FIGURE: 1 / 1

            Mel-18 Antibody (A303-580A) in WB

            Detection of human Mel-18 by western blot. Samples: Whole cell lysate from HeLa (15 and 50 µg), HEK293T (T; 50 µg) and Jurkat (J; 50 µg) cells. Antibodies: Affinity purified rabbit anti-Mel-18 antibody (Product # A303-580A) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 3 minutes.
            View Product

            Mel-18 Antibody in Western Blot (WB)

            Product Details

            A303-580A

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1:2,000-1:10,000
            -

            Immunoprecipitation (IP)

            Assay-dependent
            -
            Product Specifications

            Species Reactivity

            Human

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            Region between residue 125 and 175 of human DNA-binding Protein Mel-18.
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            1 mg/mL

            Purification

            Antigen affinity chromatography

            Storage buffer

            phosphate/tris citrate, pH 7-8

            Contains

            0.09% sodium azide

            Storage conditions

            4°C

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            Product Specific Information

            The recommended shelf life for this product is 1 year from date of receipt.

            Target Information

            The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            References (0)

            Have you cited this product in a publication?
            Let us know so we can reference it here.
            Cite this product

            Bioinformatics

            Protein Aliases: DNA-binding protein Mel-18; MGC10545; Polycomb group RING finger protein 2; RING finger protein 110; Zinc finger protein 144

            View more View less

            Gene Aliases: MEL-18; MEL18; PCGF2; RNF110; ZNF144

            View more View less

            UniProt ID: (Human) P35227

            View more View less

            Entrez Gene ID: (Human) 7703

            View more View less

            Function(s)

            DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding

            Process(es)

            negative regulation of transcription from RNA polymerase II promoter in utero embryonic development transcription, DNA-templated anterior/posterior pattern specification histone acetylation protein sumoylation embryonic skeletal system morphogenesis cellular response to hydrogen peroxide negative regulation of apoptotic signaling pathway
            It has to be done as per old AB suggested Products section.
            guarantee_icon

            Performance Guarantee

            If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

            Learn more
            help_icon

            We're here to help

            Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

            Contact tech support
            Ordering Plus Icon Minus Icon
            • Order Status
            • Order Help
            • Quick Order
            • Supply Center
            • eProcurement
            Support Plus Icon Minus Icon
            • Help and Support
            • Contact Us
            • Technical Support Centers
            • Documents and Certificates
            • Report a Site Issue
            Resources Plus Icon Minus Icon
            • Learning Centers
            • Promotions
            • Events and Webinars
            • Social Media
            About Thermo Fisher Plus Icon Minus Icon
            • About Us About Us
            • Careers Careers
            • Investors Investors
            • News News
            • Social Responsibility Social Responsibility
            • Trademarks
            Our Portfolio Plus Icon Minus Icon
            • Thermo Scientific
            • Applied Biosystems
            • Invitrogen
            • Gibco
            • Ion Torrent
            • Fisher Scientific
            • Unity Lab Services
            • Patheon
            • PPD
            • Terms & Conditions
            • Privacy Policy
            • Price & Freight Policy
            • Cookie偏好

              在此網站使用 Cookie 的選擇

              我們以及我們的附屬公司和供應商使用 cookies 和類似技術來經營我們的網站、識別我們網站的訪客、提供安全登入、收集統計資料以優化網站功能,並提供根據您的興趣量身定制的內容。點擊「全部接受」 以接受所有 cookies,並直接進入網站,或點擊「管理設定」 以查看 cookies 類型的詳細說明,並選擇是否在網站接受某些 cookies。
            © 2006-2025 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
            Hong Kong flag icon
            Hong Kong

            Your items have has been added!


            Host server : magellan-search-green-56756dfb8b-c5nb2:80/100.66.79.199:80.
            git-commit: de6905f249d25e22729e613aef254bb544bd8b7c
            git-url: https://github.com/thermofisher/magellan-search
            git-branch: release/2.31.1-2025.06.25-1.0