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Bioss

Melatonin Receptor 1A Polyclonal Antibody

View all (9) MTNR1A antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (2)

Application

Melatonin Receptor 1A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 2

Melatonin Receptor 1A Antibody (BS-0027R) in IHC (P)

Formalin-fixed and paraffin-embedded rat brain labeled with Rabbit Anti-MTNR1A/MTR-1A/MEL-1A-R Polyclonal Antibody, Unconjugated (bs-0027R) at 1:300 followed by conjugation to the secondary antibody.

Melatonin Receptor 1A Antibody in Western Blot (WB)

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Product Details

BS-0027R

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

1:300

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500

Immunocytochemistry (ICC/IF)

1:50-1:200

Flow Cytometry (Flow)

1:20-1:100

ELISA (ELISA)

1:500-1:1,000

Dot blot (DB)

Assay-dependent

Product Specifications

Species Reactivity

Bovine, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human MTR-1A, amino acids 201-280.

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Mel-1A-R; mel1a melatonin receptor; Mel1a receptor; Melatonin receptor type 1A

Gene Aliases: MEL-1A-R; MelR; MR; MT1; MTNR1A

UniProt ID: (Human) P48039, (Mouse) Q61184

Entrez Gene ID: (Human) 4543, (Mouse) 17773, (Rat) 114211

Function(s)

protein binding melatonin receptor activity hormone binding organic cyclic compound binding signal transducer activity G-protein coupled receptor activity molecular_function G-protein coupled receptor

Process(es)

cell surface receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger aging mating behavior circadian rhythm positive regulation of cGMP biosynthetic process camera-type eye development negative regulation of insulin secretion signal transduction G-protein coupled receptor signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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