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The monkeypox virus (MPXV) is the causative agent of the monkeypox disease. As a double-stranded DNA virus member of the genus Orthopoxvirus and the family Poxviridae, MPXV is similar to other pathogens of this group including variola (the causative agent of smallpox), vaccinia, and the cowpox virus. MPXV A29L, M1R and B6R, the orthologous to A27L, L1R and B5R VACV antigens respectively, are thought to be able to elicit a protective immune response against lethal MPXV challenge.
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