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Munc13-4 Antibody (PA5-18550) in IHC (P)
Immunohistochemical analysis of Munc13 4 in paraffin embedded human thymus using a Munc13 4 polyclonal antibody (Product #PA5-18550) at a concentration of 2.5 µg/mL. Steamed antigen retrieval was performed with pH 6 buffered citrate. Samples were then stained with alkaline phosphatase.
Product Details
PA5-18550
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (ETQKHKKDLHPLFD) corresponding to the internal amino acids of UNC13D (aa 967-980).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_10981103
Product Specific Information
This antibody is predicted to react with bovine, canine, porcine and rat based on sequence homology.^M
^M
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: likely ortholog of H. sapiens unc-13 homolog D (UNC13D); munc 13-4; Munc13-4; Protein unc-13 homolog D
Gene Aliases: 2610108D09Rik; FHL3; HLH3; HPLH3; Jinx; mFLJ00067; Munc13-4; UNC13D
UniProt ID: (Human) Q70J99, (Mouse) B2RUP2
Entrez Gene ID: (Human) 201294, (Mouse) 70450
granuloma formation
germinal center formation
phagocytosis
regulation of mast cell degranulation
natural killer cell degranulation
positive regulation of exocytosis
defense response to virus
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of regulated secretory pathway
exocytosis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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