Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: FFRMNSGECL GNVVSDERRV SSSGGLQNAQ FGIRRDGTLV TGYLSEEEVL DTENPFVQLL SGVVWLIRNG SIYINESQAT ECDETQETGS FSKFVNVISA RTAIGHDRKG QLVLFHADGQ TEQRGINLWE MAE
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 92%.
Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. The encoded preproprotein is proteolytically processed by furin to generate the mature enzyme, a homotetramer of two disulfide-linked homodimers. Mutations in this gene are associated with developmental stuttering in human patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha-N-acetylglucosaminyl phosphodiesterase; lysosomal alpha-N-acetylglucosaminidase; Mannose 6-phosphate-uncovering enzyme; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; Phosphodiester alpha-GlcNAcase
Gene Aliases: APAA; NAGPA; UCE
UniProt ID: (Human) Q9UK23
Entrez Gene ID: (Human) 51172
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