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Product Details
H00003340-M03
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2F11
Immunogen
NDST1 (NP_001534, 38 a.a. approximately 136 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: LYGWKRGLEP SADAPEPDCG DPPPVAPSRL LPLKPVQAAT PSRTDPLVLV FVESLYSQLG QEVVAILESS RFKYRTEIAP GKGDMPTLTD KGRGRFALI
Target Information
Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L- selectin ligands, thereby playing a role in inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [Heparan sulfate]-glucosamine N-sulfotransferase 1; Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; Glucosaminyl N-deacetylase/N-sulfotransferase 1; heparan sulfate-N-deacetylase/N-sulfotransferase; heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase 1; HSNST 1; N-Deacetylase-N-sulfotransferase 1; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; N-deacetylase/N-sulfotransferase 1; N-heparan sulfate sulfotransferase 1; N-HSST 1; NDST-1
Gene Aliases: HSST; HSST1; MRT46; NDST1; NST1
UniProt ID: (Human) P52848
Entrez Gene ID: (Human) 3340
MAPK cascade
polysaccharide biosynthetic process
cardiac septum development
glycosaminoglycan biosynthetic process
protein sulfation
inflammatory response
smoothened signaling pathway
respiratory gaseous exchange
fibroblast growth factor receptor signaling pathway
heparan sulfate proteoglycan biosynthetic process
heparin biosynthetic process
forebrain development
midbrain development
aorta development
embryonic neurocranium morphogenesis
embryonic viscerocranium morphogenesis
coronary vasculature development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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