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Product Details
H00004761-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NEUROD2 (AAH22481.1, 1 a.a. approximately 382 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MLTRLFSEPG LLSDVPKFAS WGDGEDDEPR SDKGDAPPPP PPAPGPGAPG PARAAKPVPL RGEEGTEATL AEVKEEGELG GEEEEEEEEE EGLDEAEGER PKKGGPKKRK MTKARLERSK LRRQKANARE RNRMHDLNAA LDNLRKVVPC YSKTQKLSKI ETLRLAKNYI WALSEILRSG KRPDLVSYVQ TLCKGLSQPT TNLVAGCLQL NSRNFLTEQG ADGAGRFHGS GGPFAMHPYP YPCSRLAGAQ CQAAGGLGGG AAHALRTHGY CAAYETLYAA AGGGGASPDY NSSEYEGPLS PPLCLNGNFS LKQDSSPDHE KSYHYSMHYS ALPGSRPTGH GLVFGSSAVR GGVHSENLLS YDMHLHHDRG PMYEELNAFF HN
Target Information
Members of the myogenic determination family are basic helix-loop-helix (bHLH) proteins that can be separated into two classes, both of which work together to activate DNA transcription. Class A proteins include the ubiquitously expressed E-box binding factors, namely E2A, ITF-2 and HEB, while class B proteins, such as MyoD, myogenin and Neuro D (BETA2), are transiently expressed and exhibit a much more limited tissue distribution. Neuro D2 (neurogenic differentiation 2), also known as NDRF, NEUROD2 or bHLHa1, is a 382 amino acid nuclear protein that contains one bHLH domain and functions to induce neurogenic differentiation, playing an important role in the maintenance and determination of cell fate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHa1; Class A basic helix-loop-helix protein 1; NDF2; NDR2; NDRF; NeuroD-related factor; NeuroD2; neurogenic basic-helix-loop-helix protein; neurogenic differentiation 2; Neurogenic differentiation factor 2
Gene Aliases: BHLHA1; NDRF; NEUROD2
UniProt ID: (Human) Q15784
Entrez Gene ID: (Human) 4761
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein heterodimerization activity
E-box binding
basic helix-loop-helix transcription factor
behavioral fear response
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
nervous system development
associative learning
protein ubiquitination
cerebellar cortex development
positive regulation of synaptic plasticity
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
neuron development
positive regulation of calcium-mediated signaling
positive regulation of sequence-specific DNA binding transcription factor activity
cellular response to electrical stimulus
cellular response to calcium ion
positive regulation of synapse maturation
negative regulation of nucleic acid-templated transcription
negative regulation of synapse maturation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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