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Members of the myogenic determination family are basic helix-loop-helix (bHLH) proteins that can be separated into two classes, both of which work together to activate DNA transcription. Class A proteins include the ubiquitously expressed E-box binding factors, namely E2A, ITF-2 and HEB, while class B proteins, such as MyoD, myogenin and Neuro D (BETA2), are transiently expressed and exhibit a much more limited tissue distribution. Neuro D2 (neurogenic differentiation 2), also known as NDRF, NEUROD2 or bHLHa1, is a 382 amino acid nuclear protein that contains one bHLH domain and functions to induce neurogenic differentiation, playing an important role in the maintenance and determination of cell fate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: bHLHa1; Class A basic helix-loop-helix protein 1; NDF2; NDR2; NDRF; NeuroD-related factor; NeuroD2; neurogenic basic-helix-loop-helix protein; neurogenic differentiation 2; Neurogenic differentiation factor 2
Gene Aliases: BHLHA1; NDRF; NEUROD2
UniProt ID: (Human) Q15784
Entrez Gene ID: (Human) 4761
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