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Immunogen sequence: TCARVHECD HPVYHSCHSE EKCPPCTFLT QKWCMGKHEF RSNIPCHLVD ISCGLPCSAT LPCGMHKCQR LCHKGECLVD EPCKQPCTTP RADCGHPCMA PCHTSSPCPV TACKAKVELQ CECGRRKEMV ICSEASSTYQ RIAAISMASK ITDMQLGGSV EISKLITKKE VHQARLECDE ECSALERKKR LAEAFHISED SDPFNIRSSG SKFSDSLKED ARKDLKFVSD VEKEMETLVE AVNKGKNSKK SHSFPPMNRD HRRIIHDLAQ VYGLESVSYD SEPKRNVVVT AIRGKSVCPP TTLTGVLERE MQARPPPPIP HHRHQSDKNP GSSNLQKITK EPIIDYFDVQ D (771-1120 aa encoded by BC012151)
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. NFX1 is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma.MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.
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Protein Aliases: DKFZp779G2416; m-Nfx.1; MGC20369; Nuclear transcription factor, X box-binding protein 1; testis expressed gene 42; Transcriptional repressor NF-X1; X-box binding 1
Gene Aliases: 1300017N15Rik; 3000003M19Rik; NFX.1; NFX1; NFX2; TEG-42; Tex42
UniProt ID: (Human) Q12986, (Mouse) B1AY10
Entrez Gene ID: (Human) 4799, (Rat) 313166, (Mouse) 74164
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