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Application
FIGURE: 1 / 3
NGL-3/LRRC4B (extracellular) Antibody (ANR-163-200UL) in IHC (F)
Expression of NGL-3 in mouse hippocampus - Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-NGL-3/LRRC4B (extracellular) Antibody (#ANR-163), (1:200), followed by goat Anti-rabbit-AlexaFluor-488. NGL-3 immunoreactivity (green) is detected in the pyramidal layer (arrows). Cell nuclei are stained with DAPI (blue).
Product Details
ANR-163-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)PGEEAQQPRGTEKE, corresponding to amino acid residues 498-511 of mouse NGL-3, Extracellular, N-terminus
Conjugate
Unconjugated
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
The LRRC4B gene encodes a protein known as leucine-rich repeat-containing protein 4B, which is involved in cellular signaling and neural development. LRRC4B is a member of the leucine-rich repeat (LRR) protein family, characterized by its ability to mediate protein-protein interactions through its LRR domains. This protein is predominantly expressed in the nervous system and plays a crucial role in neuronal growth, synapse formation, and signal transduction pathways essential for brain development and function. LRRC4B contributes to cell adhesion, growth cone guidance, and synaptic plasticity, influencing the formation and maintenance of neural circuits. Its dysregulation has been linked to neurodevelopmental disorders, highlighting its importance in cognitive functions and neurological health. Additionally, LRRC4B is implicated in cancer biology, where it may act as a tumor suppressor, modulating cellular proliferation and migration. Research continues to explore LRRC4B's interactions and regulatory mechanisms, offering insights into potential therapeutic applications for neurological diseases and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leucine-rich repeat-containing protein 4B; leucine-rich repeats and immunoglobulin-like domains 4; Netrin-G3 ligand; NGL-3; protein NGL-3
Gene Aliases: A830007M12; Lrig4; Lrrc4b; NGL-3
UniProt ID: (Rat) P0CC10, (Mouse) P0C192
Entrez Gene ID: (Rat) 308571, (Mouse) 272381
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