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Invitrogen
NMDAR2D Polyclonal Antibody
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Application
FIGURE: 1 / 1
NMDAR2D Antibody (PA5-87624) in WB
Western blot analysis of NMDAR2D in extracts of various cell lines. Samples were incubated with NMDAR2D Polyclonal antibody (Product # PA5-87624) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Product Details
PA5-87624
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 330-480 of human GRIN2D (NP_0008272)
Conjugate
Unconjugated
Form
Liquid
Concentration
3.65 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2804299
Product Specific Information
Immunogen sequence: GAQALLRDYG FLPELGHDCR AQNRTHRGES LHRYFMNITW DNRDYSFNED GFLVNPSLVV ISLTRDRTWE VVGSWEQQTL RLKYPLWSRY GRFLQPVDDT QHLTVATLEE RPFVIVEPAD PISGTCIRDS VPCRSQLNRT HSPPPDAPRP E; Positive Samples: SH-SY5Y, Mouse liver; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Target Information
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, whereas the NMDA receptors exhibit slow kinetsis of Ca2+ ions and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilon 1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EB11; estrogen receptor binding CpG island; GluN2D; Glutamate [NMDA] receptor subunit epsilon-4; glutamate receptor; Glutamate receptor ionotropic, NMDA 2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D; N-methyl D-aspartate receptor subtype 2D; N-methyl-d-aspartate receptor subunit 2D; NMDAR2D
Gene Aliases: EB11; GluN2D; GRIN2D; NMDAR2D; NR2D
UniProt ID: (Human) O15399
Entrez Gene ID: (Human) 2906
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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