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Product Details
IHC-00195
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residues 250 and the C-terminus (residue 307) of human N-myc and STAT interactor.
Conjugate
Form
Liquid
Concentration
50 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Gorilla, Chimpanzee, Northern white-cheeked gibbon and White-tufted-ear marmoset
Target Information
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: N-myc (and STAT) interactor; N-myc and STAT interactor; N-myc interactor; N-myc-interactor; Nmi
Gene Aliases: NMI
UniProt ID: (Human) Q13287
Entrez Gene ID: (Human) 9111
transcription from RNA polymerase II promoter
inflammatory response
JAK-STAT cascade
negative regulation of interferon-alpha biosynthetic process
negative regulation of interferon-beta biosynthetic process
negative regulation of innate immune response
interferon-gamma-mediated signaling pathway
positive regulation of protein K48-linked ubiquitination
regulation of nucleic acid-templated transcription
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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