Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: KLARCEGLAG GKARGAGATG KDTMGDLPRD PGHVVEQLSR SLQTLKDRLE SLEHQLRANV SNAGLPGDFR EVLQQRLGEL ERQLLRKVAE LEDEKSLLHN ETSAHRQKTE STLNALLQRV TELERGNSAF KSPDAFKVSL PLRTNYLYGK I; Positive Samples: SH-SY5Y, BxPC-3, LO2
Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson’s disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD.
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Protein Aliases: apexin; neuronal activity-regulated pentaxin; Neuronal pentraxin II; Neuronal pentraxin-2; NP-II; NP2
Gene Aliases: NARP; NP-II; NP2; NPTX2
UniProt ID: (Human) P47972
Entrez Gene ID: (Human) 4885
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