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NRG2 (extracellular) Antibody (PA5-111859) in IHC (F)
Immunohistochemistry analysis of NRG2 in perfusion-fixed, frozen mouse hippocampus and cerebellum tissue sections using NRG2 (extracellular) Antibody (Product # PA5-111859) at a dilution of 1:300, followed by goat anti-rabbit-AlexaFluor-488. A) NRG2 staining in CA1 hippocampal region (green) is detected in the pyramidal layer (P, arrows). B) Staining in the cerebellum (green) is observed in Purkinje cells (... View More
Product Details
PA5-111859
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to amino acid residues 297-311 of rat Neuregulin-2 (Extracellular, N-terminus)
Conjugate
Unconjugated
Form
Lyophilized
Concentration
0.8 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2857268
Product Specific Information
Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Peptide sequence is: (C)RDIRIKY GNGRKNSR
Homology: Mouse, human amino acid residues are identical.
Target Information
Neuregulin 2 is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcripts encoding distinct isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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