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Product Details
75-280-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
N312/10
Immunogen
Fusion protein amino acids 2129-2696 (C-terminus) of human NSD1 (accession number Q96L73) produced recombinantly in E. Coli.
Conjugate
FL490
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Androgen receptor coactivator 267 kDa protein; androgen receptor-associated coregulator 267; Androgen receptor-associated protein of 267 kDa; H3-K36-HMTase; H4-K20-HMTase; histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific; Histone-lysine N-methyltransferase, H3 lysine-36 specific; Lysine N-methyltransferase 3B; NR-binding SET domain-containing protein; nsd1; Nuclear receptor-binding SET domain-containing protein 1
Gene Aliases: AI528500; ARA267; KMT3B; NSD1; SOTOS; SOTOS1; STO
UniProt ID: (Human) Q96L73
Entrez Gene ID: (Human) 64324, (Mouse) 18193
RNA polymerase II core promoter sequence-specific DNA binding
chromatin binding
transcription cofactor activity
transcription corepressor activity
zinc ion binding
histone-lysine N-methyltransferase activity
estrogen receptor binding
histone methyltransferase activity (H4-K20 specific)
retinoic acid receptor binding
retinoid X receptor binding
thyroid hormone receptor binding
histone methyltransferase activity (H3-K36 specific)
androgen receptor binding
protein binding
methyltransferase activity
transferase activity
histone methyltransferase activity
metal ion binding
negative regulation of transcription from RNA polymerase II promoter
regulation of histone H3-K36 methylation
transcription, DNA-templated
histone H3-K36 methylation
histone methylation
regulation of peptidyl-serine phosphorylation
histone H4-K20 methylation
positive regulation of transcription, DNA-templated
regulation of RNA polymerase II regulatory region sequence-specific DNA binding
gastrulation with mouth forming second
regulation of transcription, DNA-templated
multicellular organism development
chromatin modification
methylation
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