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            • Primary Antibodies ›
            • TrkB Antibodies

            OriGene

            NTRK2 Monoclonal Antibody (OTI2E1), TrueMAB™

            1 Reference
            View all (76) TrkB antibodies
            Datasheet
            Protocols
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            Datasheet
            Protocols
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            Cite NTRK2 Monoclonal Antibody (OTI2E1), TrueMAB™

            • Antibody Testing Data (3)
            Application
            NTRK2 Antibody in Immunocytochemistry (ICC/IF)
            Group 53 Created with Sketch.

            FIGURE: 1 / 3

            NTRK2 Antibody (TA500386) in ICC/IF

            Anti-NTRK2 mouse monoclonal antibody (TA500386) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY NTRK2(RC205129).
            View Product

            NTRK2 Antibody in Immunocytochemistry (ICC/IF)
            NTRK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            NTRK2 Antibody in Western Blot (WB)

            Product Details

            TA500386

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1:1,000
            -

            Immunohistochemistry (Paraffin) (IHC (P))

            1:150
            -

            Immunocytochemistry (ICC/IF)

            1:100
            -

            Miscellaneous PubMed (Misc)

            -
            View 1 publication 1 publication
            Product Specifications

            Species Reactivity

            Human, Mouse, Rat

            Host/Isotype

            Mouse / IgG1

            Class

            Monoclonal

            Type

            Antibody

            Clone

            OTI2E1

            Immunogen

            Full-length protein expressed in 293T cell transfected with human NTRK2 expression vector
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            1.17 mg/mL

            Purification

            Affinity chromatography

            Storage buffer

            PBS with 1% BSA, 50% glycerol

            Contains

            0.02% sodium azide

            Storage conditions

            -20°C, Avoid Freeze/Thaw Cycles

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            Target Information

            NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses. TrkB is involved in the development and maintenance of the nervous system. Moreover, Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            Bioinformatics

            Protein Aliases: AI848316; BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; C030027L06Rik; EC 2.7.10.1; GP145 TrkB; GP145-TrkB; GP145-TrkB/GP95-TrkB; GP145TrkB; GP95 TrkB; GP95-TrkB; hyperphagia; kinase TrkB; neural receptor protein-tyrosine kinase (trkB); Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; NTRK 2; OTTHUMP00000021573; OTTHUMP00000021574; OTTHUMP00000021576; OTTHUMP00000021577; Trk B; Trk-B; TrkB tyrosine kinase; Tropomyosin-related kinase B; tyrosine kinase receptor B

            View more View less

            Gene Aliases: GP145-TrkB; GP145-TrkB/GP95-TrkB; NTRK2; RATTRKB1; Tkrb; trk-B; TRKB; TRKB1

            View more View less

            UniProt ID: (Human) Q16620, (Mouse) P15209, (Rat) Q63604

            View more View less

            Entrez Gene ID: (Human) 4915, (Mouse) 18212, (Rat) 25054

            View more View less

            Function(s)

            ATP binding receptor tyrosine kinase binding protein homodimerization activity neurotrophin binding brain-derived neurotrophic factor binding brain-derived neurotrophic factor-activated receptor activity nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity neurotrophin receptor activity protein binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups ephrin receptor binding transmembrane signal receptor immunoglobulin superfamily cell adhesion molecule

            Process(es)

            vasculogenesis neuron migration positive regulation of protein phosphorylation inflammatory response neuromuscular junction development aging learning long-term memory circadian rhythm feeding behavior positive regulation of cell proliferation response to light stimulus positive regulation of gene expression positive regulation of neuron projection development response to auditory stimulus glutamate secretion positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation central nervous system neuron development cerebral cortex development neuron differentiation brain-derived neurotrophic factor receptor signaling pathway positive regulation of peptidyl-serine phosphorylation calcium-mediated signaling using intracellular calcium source neurotrophin signaling pathway mechanoreceptor differentiation regulation of GTPase activity positive regulation of MAPK cascade negative regulation of neuron apoptotic process retinal rod cell development protein autophosphorylation regulation of neurotransmitter secretion oligodendrocyte differentiation peripheral nervous system neuron development positive regulation of axonogenesis regulation of dendrite development regulation of protein kinase B signaling positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic retina development in camera-type eye long-term synaptic potentiation cellular response to amino acid stimulus cellular response to tumor necrosis factor cellular response to brain-derived neurotrophic factor stimulus negative regulation of anoikis protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development phosphorylation regulation of metabolic process cell differentiation regulation of MAPK cascade positive regulation of glucocorticoid receptor signaling pathway cellular response to nerve growth factor stimulus
            It has to be done as per old AB suggested Products section.
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