Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-87068
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein of human NUMB.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2803821
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: h-Numb; m-Nb; m-numb; mnb; numb gene homolog; numb homolog; Protein numb homolog; Protein S171
Gene Aliases: c14_5527; C14orf41; Nb; NUMB; S171
UniProt ID: (Human) P49757, (Mouse) Q9QZS3
Entrez Gene ID: (Human) 8650, (Mouse) 18222, (Rat) 29419
axonogenesis
lateral ventricle development
neuroblast division in subventricular zone
positive regulation of cell migration
positive regulation of polarized epithelial cell differentiation
adherens junction organization
negative regulation of Notch signaling pathway
positive regulation of neurogenesis
lung epithelial cell differentiation
cell-cell adhesion
negative regulation of protein localization to plasma membrane
multicellular organism development
nervous system development
neuroblast proliferation
forebrain development
regulation of neuron differentiation
positive regulation of dendrite morphogenesis
cell proliferation
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support