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Neurofascin Antibody (PA5-47468) in IHC (F)
Immunohistochemical analysis of Neurofascin in perfusion fixed frozen sections of rat brain (dorsal root ganglion). Samples were incubated in Neurofascin polyclonal antibody (Product # PA5-47468) using a dilution of 1.7 µg/mL overnight at 4 °C followed by NorthernLights™ 557-conjugated Anti-Chicken IgY Secondary Antibody (yellow) and counterstained with DAPI (blue). Specific staining was localized to neuron... View More
产品信息
PA5-47468
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Chicken
/ IgY
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant rat Neurofascin Ile25-Ala1031
偶联物
Unconjugated
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2609964
产品详细信息
This antibody detects human, mouse, rat Neurofascin in Western blots and rat Neurofascin in direct ELISAs.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Neurofascin encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. Neurofascin undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DKFZp686P2250; KIAA0756FLJ46866; Neurofascin; neurofascin homolog
基因别名: AA387016; D430023G06Rik; KIAA0756; mKIAA0756; NF; NFASC; NRCAML
UniProt ID: (Human) O94856, (Rat) P97685, (Mouse) Q810U3
Entrez Gene ID: (Human) 23114, (Rat) 116690, (Mouse) 269116
