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Invitrogen
Neuropilin 2 Polyclonal Antibody
Application
FIGURE: 1 / 5
Neuropilin 2 Antibody (PA5-47274) in IHC (P)
Immunohistochemical analysis of Neuropilin 2 in immersion fixed paraffin-embedded sections of human pancreatic cancer tissue. Samples were incubated in Neuropilin 2 polyclonal antibody (Product # PA5-47274) using a dilution of 5 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-basic. Tissue was staine... View More
Product Details
PA5-47274
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Neuropilin-2 Gln23-Tyr855
Conjugate
Unconjugated
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2610178
Product Specific Information
In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse Neuropilin-2 is observed, and approximately 25% cross-reactivity with recombinant rat (rr) Neuropilin-2 is observed and less than 5% cross-reactivity with rrNeuropilin-1 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C) and SEMA3F protein (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F), and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Neuropilin-2; neuropilin-2a(17); neuropilin-2a(22); neuropilin-2b(0); receptor for VEGF165 and semaphorins class3; Vascular endothelial cell growth factor 165 receptor 2
Gene Aliases: 1110048P06Rik; Np-2; NP2; Npn-2; NPN2; NRP2; PRO2714; VEGF165R2
UniProt ID: (Human) O60462, (Mouse) O35375, (Rat) O35276
Entrez Gene ID: (Human) 8828, (Mouse) 18187, (Rat) 81527
angiogenesis
positive regulation of endothelial cell proliferation
cell adhesion
axon guidance
positive regulation of endothelial cell migration
nerve development
vascular endothelial growth factor signaling pathway
vascular endothelial growth factor receptor signaling pathway
axon extension involved in axon guidance
sympathetic ganglion development
sympathetic neuron projection extension
sympathetic neuron projection guidance
semaphorin-plexin signaling pathway involved in neuron projection guidance
neural crest cell migration
neuron migration
multicellular organism development
nervous system development
heart development
facial nerve structural organization
vestibulocochlear nerve structural organization
gonadotrophin-releasing hormone neuronal migration to the hypothalamus
cell differentiation
ventral trunk neural crest cell migration
negative chemotaxis
trigeminal ganglion development
ganglion morphogenesis
semaphorin-plexin signaling pathway
sensory neuron axon guidance
neural crest cell migration involved in autonomic nervous system development
facioacoustic ganglion development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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