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Bioss
Neurotensin Receptor 2 Polyclonal Antibody
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Application
FIGURE: 1 / 1
Neurotensin Receptor 2 Antibody (BS-12004R) in WB
Lane 1: Cerebrum lysates probed with Neurotensin Receptor 2 Polyclonal Antibody, Unconjugated (bs-12004R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.
Product Details
BS-12004R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Neurotensin Receptor 2, amino acids 151-250.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: High-affinity levocabastine-sensitive neurotensin receptor; Levocabastine-sensitive neurotensin receptor; low affinity neurotensin receptor; Low-affinity levocabastine-sensitive neurotensin receptor; Neurotensin receptor type 2; neurotensin receptor, type 2; NT-R-2; NT2 receptor; NTR2; NTR2 receptor; NTRL
Gene Aliases: NT2R; NTR2; NTRL; NTSR2
UniProt ID: (Human) O95665, (Rat) Q63384, (Mouse) P70310
Entrez Gene ID: (Human) 23620, (Rat) 64636, (Mouse) 18217
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