Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
MA1-760
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Many
Published species
Fish,
Hamster,
Human,
Pig
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
5C.6
Immunogen
Purified NCC cells from catfish.
Conjugate
Form
Liquid
Concentration
0.73 mg/mL
Purification
purified
Storage buffer
PBS with 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_326367
Product Specific Information
MA1-760 detects nonspecific cytotoxic cells (NCC) from catfish and tilapia tissues and also detects natural killer/lymphokine activated killer (NK/LAK) cells from rat, bovine, equine, canine and porcine tissues. MA1-760 has been successfully used in Western blot, cytotoxic inhibition studies with NCC/NK/LAK cells, FACS, immunoprecipitation, panning, and ELISA procedures. By Western blot, this antibody detects a 32 kDa protein representing nonspecific cytotoxic cell receptor protein. In cytotoxicity assays, this antibody is used under saturating conditions to inhibit target cell conjugation. The MA1-760 immunogen is purified NCC cells from catfish.
Target Information
Non-specific cytotoxic cells (NCCs) in teleosts and their evolutionary homologue are a subpopulation of lymphocytes with properties that distinguish them from either B- or T-cells. One such property is that NCC/natural killer (NK)/lymphokine activated killer (LAK) cells express spontaneous, non-major histocompatibility complex restricted cytotoxic activity. NCC and LAK lyse a variety of transformed murine and human B-cell, T-cell and myeloid targets. A 32 kDa membrane protein [non-specific cytotoxic cell receptor protein (NCCRP-1)] expressed by NCC and certain mammalian NK/LAK cells mediates this cytotoxicity. NCCRP-1 is evolutionarily conserved and is found in species ranging from marine and freshwater teleosts to higher mammals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Natural Killer Cell; NCC/NK
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support