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Proteintech

OAS3 Polyclonal Antibody

10 篇参考文献

查看其他6个OAS3抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (9)

Application

OAS3 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 9

OAS3 Antibody (21915-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 21915-1-AP (OAS3 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

OAS3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

21915-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

查看7篇已发表文章 7篇已发表文章

免疫组化 (IHC)

查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

1:20-1:200

不适用 (N/A)

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

OAS3 Fusion Protein Ag16150 (1-350 aa encoded by BC113746)

查看免疫原

偶联物

Unconjugated

形式

Liquid

浓度

0.39 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MDLYSTPAA ALDRFVARRL QPRKEFVEKA RRALGALAAA LRERGGRLGA AAPRVLKTVK GGSSGRGTAL KGGCDSELVI FLDCFKSYVD QRARRAEILS EMRASLESWW QNPVPGLRLT FPEQSVPGAL QFRLTSVDLE DWMDVSLVPA FNVLGQAGSG VKPKPQVYST LLNSGCQGGE HAACFTELRR NFVNIRPAKL KNLILLVKHW YHQVCLQGLW KETLPPVYAL ELLTIFAWEQ GCKKDAFSLA EGLRTVLGLI QQHQHLCVFW TVNYGFEDPA VGQFLQRQLK RPRPVILDPA DPTWDLGNGA AWHWDLLAQE AASCYDHPCF LRGMGDPVQS WKGPGLPRAG C (1-350 aa encoded by BC113746)

靶标信息

OAS3 is an interferon inducible protein that belongs to the 2-5A synthetase family, may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate. OAS3 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. The protein is present at high level in placenta trophoblast.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

IFI44L as a novel epigenetic silencing tumor suppressor promotes apoptosis through JAK/STAT1 pathway during lung carcinogenesis.

Environmental pollution (Barking, Essex : 1987)

Zeng Y,Chen HQ,Zhang Z,Fan J,Li JZ,Zhou SM,Wang N,Yan SP,Cao J,Liu JY,Zhou ZY,Liu WB

Wed Feb 15 00:00:00 UTC 2023

Systematic Analysis of Molecular Subtypes Based on the Expression Profile of Immune-Related Genes in Pancreatic Cancer.

Oxidative medicine and cellular longevity

Ke M

Tue Dec 27 00:00:00 UTC 2022

EV71 3C protease cleaves host anti-viral factor OAS3 and enhances virus replication.

Virologica Sinica

Zhou X,Tian L,Wang J,Zheng B,Zhang W

Wed Jun 01 00:00:00 UTC 2022

OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1‒Induced Jak1‒Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis.

The Journal of investigative dermatology

Huang YZ,Zheng YX,Zhou Y,Xu F,Cui YZ,Chen XY,Wang ZY,Yan BX,Zheng M,Man XY

Sat Oct 01 00:00:00 UTC 2022

IFN-β1b induces OAS3 to inhibit EV71 via IFN-β1b/JAK/STAT1 pathway.

Virologica Sinica

Zheng B,Zhou X,Tian L,Wang J,Zhang W

Sat Oct 01 00:00:00 UTC 2022

Deficiency of ER Ca²⁺ sensor STIM1 in AgRP neurons confers protection against dietary obesity.

Cell reports

Chen Z,Pan S,Yin K,Zhang Y,Yuan X,Wang S,Yang S,Shen Q,Tang Y,Li J,Wang Y,Lu Y,Zhang G

Tue Oct 19 00:00:00 UTC 2021

Identification of potential immune-related circRNA-miRNA-mRNA regulatory network in cutaneous squamous cell carcinoma.

American journal of cancer research

Wei Y,Yang X,Gao L,Yang J,Zheng L,Gao L,Zhou X,Xiang X,Zhang J,Yi C

Sat Nov 13 00:00:00 UTC 2021

Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting.

Nature communications

Liu W,Xie L,He YH,Wu ZY,Liu LX,Bai XF,Deng DX,Xu XE,Liao LD,Lin W,Heng JH,Xu X,Peng L,Huang QF,Li CY,Zhang ZD,Wang W,Zhang GR,Gao X,Wang SH,Li CQ,Xu LY,Liu W,Li EM

Mon Aug 16 00:00:00 UTC 2021

A prenylated dsRNA sensor protects against severe COVID-19.

Science (New York, N.Y.)

Wickenhagen A,Sugrue E,Lytras S,Kuchi S,Noerenberg M,Turnbull ML,Loney C,Herder V,Allan J,Jarmson I,Cameron-Ruiz N,Varjak M,Pinto RM,Lee JY,Iselin L,Palmalux N,Stewart DG,Swingler S,Greenwood EJD,Crozier TWM,Gu Q,Davies EL,Clohisey S,Wang B,Trindade Maranhão Costa F,Freire Santana M,de Lima Ferreira LC,Murphy L,Fawkes A,Meynert A,Grimes G,Da Silva Filho JL,Marti M,Hughes J,Stanton RJ,Wang ECY,Ho A,Davis I,Jarrett RF,Castello A,Robertson DL,Semple MG,Openshaw PJM,Palmarini M,Lehner PJ,Baillie JK,Rihn SJ,Wilson SJ

Fri Oct 29 00:00:00 UTC 2021

Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression.

iScience

Fu Y,Fang Y,Lin Z,Yang L,Zheng L,Hu H,Yu T,Huang B,Chen S,Wang H,Xu S,Bao W,Chen Q,Sun L

Fri Apr 24 00:00:00 UTC 2020

生物信息学

蛋白别名: (2-5')oligo(A) synthase 3; (2-5')oligo(A) synthetase 3; 2'-5'-oligoadenylate synthase 3; 2'-5'-oligoadenylate synthetase 3, 100kDa; 2'-5'oligoadenylate synthetase p100; 2-5A synthase 3; 2-5A synthetase 3; p100 OAS; p100OAS

基因别名: OAS3; P/OKcl.4; p100; p100OAS

UniProt ID: (Human) Q9Y6K5

Entrez Gene ID: (Human) 4940

功能

2'-5'-oligoadenylate synthetase activity double-stranded RNA binding protein binding ATP binding metal ion binding nucleotidyltransferase

参与通路

nucleobase-containing compound metabolic process response to virus negative regulation of viral genome replication defense response to virus interferon-gamma-mediated signaling pathway type I interferon signaling pathway regulation of ribonuclease activity