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Product Details
PA5-102149
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human OPRD1(Accession P41143), corresponding to amino acid residues C337-A372.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2851573
Product Specific Information
Antibody detects endogenous levels of total OPRD1.
Target Information
OPRD1 is an Opioid Receptor that is involved in the control of anxiety, depression, and pain. It is a promising target in the therapy of mood-altering disorders and drug addiction. Delta and kappa opioid receptors function synergistically by forming heterodimers. OPRD1 expression has been reported primarily in the brain. High OPRD1 expression has been documented in the cortex, caudate, hippocampus, nucleus accumbens, and putamen; low OPRD1 expression has been identified in the cerebellum, hypothalamus, substantia nigra, and thalamus. OPRD1 expression is reduced in the putamen and amygdala of Alzheimer's patients and in the putamen in Parkinson's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: D-OR-1; delta 1 opioid receptor; delta opioid receptor 1; Delta-type opioid receptor; DOR-1; K56; MSL-2; Opioid receptor; opioid receptor, delta 1
Gene Aliases: DOR; DOR-1; mDOR; Nbor; OPRD; OPRD1
UniProt ID: (Human) P41143, (Mouse) P32300
Entrez Gene ID: (Human) 4985, (Mouse) 18386
protein import into nucleus, translocation
immune response
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
chemical synaptic transmission
adult locomotory behavior
negative regulation of gene expression
sensory perception of pain
negative regulation of protein oligomerization
positive regulation of CREB transcription factor activity
positive regulation of peptidyl-serine phosphorylation
opioid receptor signaling pathway
eating behavior
regulation of mitochondrial membrane potential
regulation of calcium ion transport
regulation of sensory perception of pain
cellular response to growth factor stimulus
cellular response to hypoxia
cellular response to toxic substance
signal transduction
adenylate cyclase-activating dopamine receptor signaling pathway
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