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Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: VGPGANVSLR CAGRLRNMSF VLYREGVAAP LQYRHSAQPW ADFTLLGARA PGTYSCYYH
Recently, a novel member of the leukocyte receptor complex (LRC) encoded family has been identified that is expressed specifically in osteoclast (OC). This protein names OC-associated receptor or OSCAR, play critical roles in the regulation of both innate and adaptive immune responses and bone-specific regulator of OC differentiation. Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This protein family plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MGC33613; osteoclast associated receptor OSCAR-S1; osteoclast associated receptor OSCAR-S2; Osteoclast-associated immunoglobulin-like receptor; Osteoclast-associated receptor; PIgR-3; poly-Ig receptor 3; Polymeric immunoglobulin receptor 3
Gene Aliases: OSCAR; PIgR-3; PIGR3
UniProt ID: (Human) Q8IYS5
Entrez Gene ID: (Human) 126014
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