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Invitrogen

PAR1 Monoclonal Antibody (ATAP2)

1 Published Figure

8 References

View all (22) PAR1 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Published Figures (1)

Application

FIGURE: 1 / 1

PAR1 Antibody (35-2200) in WB

Experimental cell research 2007 - Published figure using PAR1 monoclonal antibody (Product # 35-2200) in Western Blot

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Product Details

35-2200

Applications

Tested Dilution

Publications

Western Blot (WB)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

Assay-dependent

Flow Cytometry (Flow)

Assay-dependent

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

Neutralization (Neu)

View 3 publications 3 publications

Blocking Assay (BLOCK)

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Non-human primate

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

ATAP2

Immunogen

A synthetic peptide corresponding to the N-terminal region of the human thrombin receptor PAR1.

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2533198

Target Information

Thrombin is a serine protease that is involved in platelet aggregation and blood coagulation. It is cleaved from its precursor, prothrombin, and converts fibrinogen to fibrin in the final step of the clotting cascade. Thrombin mediates its regulatory effects by activating cell surface G-protein coupled receptors which include PAR-1, PAR-2 and PAR3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Activated protein C enhances cell motility of endothelial cells and MDA-MB-231 breast cancer cells by intracellular signal transduction.

Experimental cell research

Gramling MW,Beaulieu LM,Church FC

35-2200 was used in blocking or activating experiment to elucidate the mechanism by which APC promotes angiogenesis and breast cancer invasion

Mon Feb 01 00:00:00 UTC 2010

Analysis of protease-activated receptor-1 and -2 in human scar formation.

The Journal of pathology

Materazzi S,Pellerito S,Di Serio C,Paglierani M,Naldini A,Ardinghi C,Carraro F,Geppetti P,Cirino G,Santucci M,Tarantini F,Massi D

35-2200 was used in immunohistochemistry (paraffin) to examine expression and biological activity of PAR-1 and PAR-2 in normal and pathological cutaneous scars.

Wed Aug 01 00:00:00 UTC 2007

Activated protein C promotes breast cancer cell migration through interactions with EPCR and PAR-1.

Experimental cell research

Beaulieu LM,Church FC

35-2200 was used in blocking or activating experiment to examine the role of activated protein C in cell chemotaxis and invasion

Thu Feb 15 00:00:00 UTC 2007

Activated protein C promotes breast cancer cell migration through interactions with EPCR and PAR-1.

Experimental cell research

Beaulieu LM,Church FC

35-2200 was used in blocking or activating experiment to examine the role of activated protein C in cell chemotaxis and invasion

Thu Feb 15 00:00:00 UTC 2007

Expression of protease-activated receptor-1 and -2 in orofacial granulomatosis.

Oral diseases

Ketabchi S,Massi D,Ficarra G,Rubino I,Franchi A,Paglierani M,Simoni A,Capodiferro S,Favia G,Maiorano E,Tarantini F,Cirino G,Santucci M

35-2200 was used in immunohistochemistry - paraffin section to determine the expression of PAR-1, PAR-2, MMP-2, MMP-9, COX-1, and COX-2 in patients with orofacial granulomatosis

Sun Jul 01 00:00:00 UTC 2007

Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.

The Journal of biological chemistry

O'Brien PJ,Prevost N,Molino M,Hollinger MK,Woolkalis MJ,Woulfe DS,Brass LF

Fri May 05 00:00:00 UTC 2000

Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.

The Journal of biological chemistry

O'Brien PJ,Prevost N,Molino M,Hollinger MK,Woolkalis MJ,Woulfe DS,Brass LF

Fri May 05 00:00:00 UTC 2000

Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.

The Journal of biological chemistry

O'Brien PJ,Prevost N,Molino M,Hollinger MK,Woolkalis MJ,Woulfe DS,Brass LF

Fri May 05 00:00:00 UTC 2000

Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.

The Journal of biological chemistry

O'Brien PJ,Prevost N,Molino M,Hollinger MK,Woolkalis MJ,Woulfe DS,Brass LF

Fri May 05 00:00:00 UTC 2000

Bioinformatics

Protein Aliases: C HTR; coagulation factor II (thrombin) receptor; Coagulation factor II receptor; PAR-1; protease activated receptor 1; protease-activated receptor 1; Proteinase-activated receptor 1; Thrombin receptor

Gene Aliases: CF2R; F2R; HTR; PAR-1; PAR1; TR

UniProt ID: (Human) P25116

Entrez Gene ID: (Human) 2149

Function(s)

G-protein alpha-subunit binding G-protein coupled receptor activity receptor binding protein binding thrombin receptor activity G-protein beta-subunit binding G-protein coupled receptor

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PAR1 Monoclonal Antibody (ATAP2)

PAR1 Antibody (35-2200) in WB

Product Details

35-2200

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

ELISA (ELISA)

Neutralization (Neu)

Blocking Assay (BLOCK)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Function(s)

Process(es)

Performance Guarantee

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