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Immunogen sequence: YGLGVTRILA AAIEVLSTED CVRWPSLLAP YQACLIPPKK GSKEQAASEL IGQLYDHITE AVPQLHGEVL LDDRTHLTIG NRLKDANKFG YP
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 85%.
This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of proline to tRNA molecules. Mutations have been found in this gene in some patients with Alpers syndrome. [provided by RefSeq, Mar 2015]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Probable proline--tRNA ligase, mitochondrial; proline tRNA ligase 2, mitochondrial (putative); Prolyl-tRNA synthetase; Prolyl-tRNA synthetase 2, mitochondrial; ProRS
Gene Aliases: MT-PRORS; PARS2; proRS
UniProt ID: (Human) Q9H6S5
Entrez Gene ID: (Human) 25973
Molecular Function:
aminoacyl-tRNA synthetase
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