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MA5-17144 targets PBK in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human samples.
The MA5-17144 immunogen is purified recombinant fragment of human PBK expressed in E. Coli.
MA5-17144 detects PBK which has a predicted molecular weight of approximately 36kDa.
PBK (TOPK) is a serine/threonine kinase that is related to the dual specific mitogen-activated protein kinase (MAPKK). The kinase is up-regulated in a variety of hematological malignancies, participates in activating lymphoid cells, and supports testicular function (spermatogenesis). Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cancer/testis antigen 84; CT84; epididymis luminal protein 164; Lymphokine-activated killer T-cell-originated protein kinase; MAPKK-like protein kinase; Nori-3; PDZ-binding kinase; serine/threonine protein kinase; Spermatogenesis-related protein kinase; SPK; T-LAK cell-originated protein kinase
Gene Aliases: CT84; HEL164; Nori-3; PBK; SPK; TOPK
UniProt ID: (Human) Q96KB5
Entrez Gene ID: (Human) 55872
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