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Application
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PC6 Antibody (16470-1-AP) in IHC (P)
Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using (Product # 16470-1-AP) (PCSK5 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).
Product Details
16470-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PC6 Fusion Protein Ag9552 (32-351 aa encoded by BC012064)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.18 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TRVYTNHWA VKIAGGFPEA NRIASKYGFI NIGQIGALKD YYHFYHSRTI KRSVISSRGT HSFISMEPKV EWIQQQVVKK RTKRDYDFSR AQSTYFNDPK WPSMWYMHCS DNTHPCQSDM NIEGAWKRGY TGKNIVVTIL DDGIERTHPD LMQNYDALAS CDVNGNDLDP MPRYDASNEN KHGTRCAGEV AAAANNSHCT VGIAFNAKIG GVRMLDGDVT DMVEAKSVSF NPQHVHIYSA SWGPDDDGKT VDGPAPLTRQ AFENGVRMGR RGLGSVFVWA SGNGGRSKDH CSCDGYTNSI YTISISSTAE SGKKPWYLEE C (32-351 aa encoded by BC012064)
Target Information
PCSK5 belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. PCSK5 mediates posttranslational endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Two alternatively spliced transcripts are described for this gene but only one has its full length nature known. The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein mediates posttranslational endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Two alternatively spliced transcripts are described for this gene but only one has its full length nature known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: PC5; PC6; prohormone convertase 5; Proprotein convertase 5; Proprotein convertase 6; proprotein convertase PC5; Proprotein convertase subtilisin/kexin type 5; protease PC6; SPC6; subtilase; Subtilisin-like proprotein convertase 6; Subtilisin/kexin-like protease PC5
Gene Aliases: b2b1549Clo; b2b585Clo; PC5; PC5/6A; PC5A; PC6; PC6A; PCSK5; SPC6
UniProt ID: (Human) Q92824, (Mouse) Q04592
Entrez Gene ID: (Human) 5125, (Mouse) 18552
kidney development
renin secretion into blood stream
cardiac septum development
signal peptide processing
cell-cell signaling
determination of left/right symmetry
heart development
embryo implantation
anterior/posterior pattern specification
protein processing
peptide hormone processing
viral life cycle
respiratory tube development
nerve growth factor processing
limb morphogenesis
cytokine biosynthetic process
peptide biosynthetic process
embryonic digestive tract development
embryonic skeletal system development
coronary vasculature development
proteolysis
female pregnancy
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