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Fabgennix
PDE8A Polyclonal Antibody
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Application
FIGURE: 1 / 1
PDE8A Antibody (PD8A-112AP) in WB
WB of PD8A-112AP with non-reduced and heated samples listed below. 1:500 antibody dilution in DiluOBuffer (FGI-1963) at room temperature for 2 hours. Lane 1: SDS-solubilied PDE8 cell cytosol Lane 2: SDS-solubilized treated-PDE8 cell cytosol Lane 3: SDS-solubilized PDE8 cell membrane.
Product Details
PD8A-112AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic cyclic peptide from mid-region common to all PDE8A variants.
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families. Different PDEs can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Diversity in structure and specificity of function make PDEs promising targets for the pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., 2000).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cAMP-specific cyclic nucleotide phosphodiesterase 8A; cAMP-specific cyclic nucleotide phosphodiesterase PDE8; FLJ16150; High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; MmPDE8
Gene Aliases: AI551852; HsT19550; Pde8; PDE8A; RNPDE8A
UniProt ID: (Human) O60658, (Mouse) O88502
Entrez Gene ID: (Human) 5151, (Mouse) 18584, (Rat) 308776
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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