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Invitrogen

PDGFRB Monoclonal Antibody (K.596.7)

Name: PDGFRB Monoclonal Antibody (K.596.7)
Brand: Invitrogen
SKU: MA515103
Price: 456.0 USD

Advanced Verification

1 Published Figure

2 References

View all (92) PDGFRB (CD140b) antibodies

Datasheet

Protocols

Questions & Answers

Catalog # MA5-15103

Price (USD)

456.00

100 µL

Estimated availability date: 18-Jun-2025

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Datasheet

Protocols

Questions & Answers

Application

FIGURE: 1 / 3

PDGFRB Antibody (MA5-15103) in WB

Western blot analysis of PDGF Receptor beta in NIH-3T3 cell lysates using PDGF Receptor beta monoclonal antibody (Product # MA5-15103).

PDGFRB Antibody in Immunocytochemistry (ICC/IF)

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Product Details

MA5-15103

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

1:50

Functional Assay (Functional)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

K.596.7

Immunogen

Recombinant human PDGF receptor ß protein

Conjugate

Unconjugated

Form

Liquid

Concentration

1.75 mg/mL

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_10979500

Product Specific Information

It is not recommended to aliquot this antibody.

This antibody is not cross-reactive with PDGF receptor -alpha.

Target Information

PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Simultaneously targeting cancer-associated fibroblasts and angiogenic vessel as a treatment for TNBC.

The Journal of experimental medicine

Sharma M,Turaga RC,Yuan Y,Satyanarayana G,Mishra F,Bian Z,Liu W,Sun L,Yang J,Liu ZR

Published figure using PDGFRB monoclonal antibody (Product # MA5-15103) in Immunocytochemistry

Mon Apr 05 00:00:00 UTC 2021

A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Sweeney MD,Sagare AP,Pachicano M,Harrington MG,Joe E,Chui HC,Schneider LS,Montagne A,Ringman JM,Fagan AM,Morris JC,Pa J,Nation DA,Toga AW,Zlokovic BV

MA5-15103 was used in sPDGFRβ Assay to develop standard operating procedures for a highly sensitive and reproducible sPDGFRβ immunoassay with a dynamic range from 100 to 26,000 pg/mL, and confirmed elevated CSF sPDGFRβ levels in individuals with cognitive dysfunction.

Mon Jun 01 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140b; CD140b antigen; PDGF beta chain; PDGF Receptor beta; PDGF-R-beta; PDGFR-1; PDGFR-beta; Platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; Platelet-derived growth factor receptor, beta; platelet-derived growth factor receptor, beta polypeptide

Gene Aliases: AI528809; CD140B; IBGC4; IMF1; JTK12; KOGS; PDGFR; PDGFR-1; PDGFR1; PDGFRB; PENTT

UniProt ID: (Human) P09619, (Rat) Q05030, (Mouse) P05622

Entrez Gene ID: (Human) 5159, (Rat) 24629, (Mouse) 18596

Function(s)

protein tyrosine kinase activity platelet activating factor receptor activity platelet-derived growth factor-activated receptor activity platelet-derived growth factor beta-receptor activity Ras guanyl-nucleotide exchange factor activity receptor binding platelet-derived growth factor receptor binding protein binding ATP binding protein kinase binding vascular endothelial growth factor binding phosphatidylinositol 3-kinase binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity platelet-derived growth factor binding protein kinase activity signal transducer activity kinase activity nucleotide binding transmembrane receptor protein tyrosine kinase activity transferase activity transferase activity, transferring phosphorus-containing groups transmembrane signal receptor

Process(es)

Performance Guarantee

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