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Invitrogen
PDX1 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 9
PDX1 Antibody (PA5-78024) in IHC (P)
PDX1 Polyclonal Antibody detects PDX1 protein at nucleus by immunohistochemical analysis. Sample: Paraffin-embedded mouse pancreas. PDX1 stained by PDX1 Polyclonal Antibody (Product # PA5-78024) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Product Details
PA5-78024
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human PDX1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.92 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2736337
Product Specific Information
Positive Control: Jurkat, Raji, NCI-H929, mouse liver, rat liver, AsPC-1, mouse pancreas
Predicted Reactivity: Dog (100%), Pig (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DLDBP; Glucose-sensitive factor; GSF; IDX-1; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; insulin promotor factor 1; Insulin upstream factor 1; IPF-1; Islet/duodenum homeobox 1; Islet/duodenum homeobox-1; IUF-1; Pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox gene 1; pancreatic-duodenal homeobox factor 1; PDHX; PDX-1; somatostatin transactivating factor 1; somatostatin transcription factor 1; Somatostatin-transactivating factor 1; STF-1
Gene Aliases: GSF; IDX-1; Idx1; IPF-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; PDX1; STF-1; STF1
UniProt ID: (Human) P52945, (Rat) P52947, (Mouse) P52946
Entrez Gene ID: (Human) 3651, (Rat) 29535, (Mouse) 18609
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor binding
protein complex binding
protein heterodimerization activity
DNA binding
protein binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
liver development
type B pancreatic cell differentiation
glucose metabolic process
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
smoothened signaling pathway
nitric oxide mediated signal transduction
central nervous system development
positive regulation of cell proliferation
negative regulation of cell proliferation
response to wounding
response to glucose
response to iron(II) ion
response to chlorate
organ senescence
positive regulation of cell death
response to organic cyclic compound
morphogenesis of embryonic epithelium
insulin secretion
cell differentiation
pancreas development
exocrine pancreas development
endocrine pancreas development
organ regeneration
response to nutrient levels
positive regulation of insulin secretion
response to vitamin
response to lipid
response to cytokine
response to nicotine
positive regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of cell proliferation
response to drug
glucose homeostasis
response to leucine
response to alkaloid
positive regulation of DNA binding
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
stem cell differentiation
response to glucocorticoid
detection of glucose
transdifferentiation
response to fatty acid
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of type B pancreatic cell apoptotic process
multicellular organism development
regulation of gene expression
generation of precursor metabolites and energy
organ morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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